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Connect with NATPARA Patient Ambassadors

Chapters
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The NATPARA Shire Patient Ambassador Program enables patients to connect directly with real hypoparathyroidism patients to share their experiences through:

Live Events

  • Live meetings in your area will feature healthcare experts and Patient Ambassadors discussing hypoparathyroidism and treatment with NATPARA
  • These gatherings allow patients to receive education from NATPARA Patient Ambassadors 
 in a positive environment
Ambassador: Cece

Cece

Cece is in her 50s and is a parent and charity outreach coordinator.

MEDICAL HISTORY
  • Cece had her thyroid removed due to thyroid cancer
  • She was diagnosed with chronic hypoparathyroidism 6 months after surgery
  • Before starting NATPARA, Cece was taking 3000 mg of oral calcium and 0.5 to 1 mcg of active vitamin D per day
TREATMENT COURSE WITH NATPARA
  • Daily dose of NATPARA was adjusted to 75 mcg over the course of several months
  • Dose of oral calcium was gradually reduced to 1500 mg per day along with 0.25 mcg of active vitamin D

“I still need to manage my hypoparathyroidism, and I’m thankful to have NATPARA to help me with that. I have been able to decrease my calcium and vitamin D over time.”

“I still need to manage my hypoparathyroidism, and I’m thankful to have NATPARA to help me with that. I have been able to decrease my calcium and vitamin D over time.”

NATPARA may cause serious side effects, including:
High blood calcium (hypercalcemia)

  • NATPARA can cause some people to have a higher blood calcium level than normal.
    • Your doctor should check your blood calcium before you start and during your treatment with NATPARA.
    • Tell your doctor if you have nausea, vomiting, constipation, low energy, or muscle weakness. These may be signs that you have too much calcium in your blood.
Ambassador: Melissa

Melissa

Melissa is in her 50s, a parent, and a microbiologist

MEDICAL HISTORY
  • Melissa had her thyroid removed due to a multinodular goiter
  • She was diagnosed with chronic hypoparathyroidism about 1 year after surgery
  • Before starting NATPARA, Melissa was taking 3600 mg of oral calcium and 2 mcg of active vitamin D daily
TREATMENT COURSE WITH NATPARA
  • She and her endocrinologist researched treatment options and she was prescribed NATPARA
  • Daily dose of NATPARA was adjusted to 75 mcg over the course of several months
  • Dose of oral calcium was gradually reduced to 1000 mg of calcium per day and no active vitamin D

“My endo and I both reached out to the insurance company, and to OnePath, Shire’s product support service, about co-pay assistance. Everyone I talked to was great and very supportive.”

“I reached out to the insurance company, and to OnePath, Shire's product support service, for information about co-pay assistance. Everyone I talked to was great and very supportive.”

NATPARA helped reduce the need for oral calcium supplements and reduced or removed the need for active vitamin D

In a 24-week clinical study in 124 adults with hypoparathyroidism:

  • To prove the efficacy of NATPARA, by the end of the study patients had to have their:
    • Dose of active vitamin D reduced by at least 50%
    • Dose of calcium reduced by at least 50%
    • Blood calcium level in a certain target range (between 7.5 mg/dL and 10.6 mg/dL)
55 Percent

of patients who received NATPARA reduced their active vitamin D and oral calcium use by at least half while maintaining calcium levels in the blood within a target range compared with 3% in the placebo groupa,b

42 Percent

of patients who received NATPARA were able to stop all use of active vitamin D, and to reduce their oral calcium to no more than 500 mg per day compared with 3% in the placebo groupa,b

69 Percent

of patients who received NATPARA reduced their oral calcium use by at least half compared with 8% in the placebo groupa,b

aAt the end of the clinical study, there were no differences in the percentage of patients with serum calcium levels between 7.5 mg/dL and 10.6 mg/dL in the NATPARA (86.9%) and placebo (87.5%) groups.

bOf the 124 adult patients, 84 were taking NATPARA and 40 were taking placebo.

Ambassador: Chrissy

Chrissy

Chrissy is in her 40s and is a stay-at-home mom

Medical History
  • Chrissy was diagnosed with thyroid cancer and had her thyroid removed
  • She was diagnosed with hypoparathyroidism 6 months after surgery
  • Before starting NATPARA, Chrissy was taking about 5000 mg of oral calcium and 0.75 mcg of active vitamin D daily
Treatment Course With NATPARA
  • She and her endocrinologist researched treatment options and she was prescribed NATPARA
  • Daily dose of NATPARA was adjusted to 100 mcg over time
  • Her oral calcium was gradually reduced to 1600 mg per day and she no longer takes vitamin D
  • Her albumin-corrected total serum calcium has been maintained at 8.1 mg/dL

“Since I started taking NATPARA, over time I was able to reduce the amount of calcium and vitamin D that I take.”

“Since I started taking NATPARA, over time I was able to reduce the amount of calcium and vitamin D that I take.”

NATPARA may cause serious side effects, including:
Low blood calcium (hypocalcemia)

  • People who stop using or miss a dose of NATPARA may have an increased risk of severe low blood calcium levels
  • Tell your doctor if you have tingling of your lips, tongue, fingers and feet, twitching of face muscles, cramping of feet and hands, seizures, depression, or have problems thinking or remembering
  • Tell your doctor right away if you have any of these signs and symptoms of high or low blood calcium levels
Ambassador: Cate

Cate

Cate is in her 40s, married, and an accounting professional.

Medical History
  • The cause of Cate’s hypoparathyroidism is unknown, or “idiopathic.” She never had surgery or issues with her thyroid prior to diagnosis
  • Her symptoms began gradually over time
  • Before starting NATPARA, Cate was taking more than 5000 mg of oral calcium and 0.5 mcg of active vitamin D daily
Treatment Course With NATPARA
  • She and her endocrinologist researched treatment options and she was prescribed NATPARA
  • Daily dose of NATPARA adjusted to 100 mcg over the course of several months
  • She gradually reduced to 500 mg of oral calcium and 0.25 mcg of active vitamin D per day, checking blood levels often
  • Her albumin-corrected total serum calcium has been maintained

“When I started treatment with NATPARA, I worked very closely with my doctor to monitor my calcium levels. If there’s any fluctuation with my labs or how I feel overall, he’s prepared me to figure out how to deal with it.”

“When I started treatment with NATPARA, I worked very closely with my doctor to monitor my calcium levels. If there’s any fluctuation with my labs or how I feel overall, he’s prepared me to figure out how to deal with it.”

NATPARA® is a registered trademark of Shire-NPS Pharmaceuticals, Inc.

OnePath® is a registered trademark of Shire or its affiliates.

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SHIRE and the Shire logo are trademarks or registered trademarks of Shire Pharmaceutical Holdings Ireland Limited or its affiliates.