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NATPARA is a prescription parathyroid hormone used with calcium and vitamin D to control low blood calcium (hypocalcemia) in people with low parathyroid hormone blood levels (hypoparathyroidism). It is only for people who do not respond well to treatment with calcium and active forms of vitamin D alone, because it may increase the possible risk of bone cancer (osteosarcoma).

NATPARA was not studied in people with hypoparathyroidism caused by calcium-sensing receptor mutations. It was not studied in people who get sudden hypoparathyroidism after surgery. It is not known if NATPARA is safe and effective for children 18 years of age and younger. NATPARA should not be used in children and young adults whose bones are still growing.

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NATPARA is a prescription parathyroid hormone used with calcium and vitamin D to control low blood calcium (hypocalcemia) in people with low parathyroid hormone blood levels (hypoparathyroidism). It is only for people who do not respond well to treatment with calcium and active forms of vitamin D alone, because it may increase the possible risk of bone cancer (osteosarcoma).

NATPARA was not studied in people with hypoparathyroidism caused by calcium-sensing receptor mutations. It was not studied in people who get sudden hypoparathyroidism after surgery. It is not known if NATPARA is safe and effective for children 18 years of age and younger. NATPARA should not be used in children and young adults whose bones are still growing.

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Get help through OnePath

A product support program to help you get started on NATPARA

Shire is committed to supporting patients with hypoparathyroidism on their treatment journey. OnePath is a free product support program for eligible adults with hypoparathyroidism who have been prescribed NATPARA.

OnePath is here to help. Our Patient Support Managers are experienced partners who work with you one-on-one to make sure you have access to your prescribed therapy. And, beyond your prescription, we can provide you with a range of resources as you move forward.

OnePath Product Support

How OnePath can help

Meet your OnePath Team

Once enrolled in OnePath, you will receive a dedicated Patient Support Manager (PSM) and may meet with a local Patient Access Manager (PAM)

Your PSM will:

  • Facilitate insurance benefits verification and discuss your benefits with you
  • Work with a specialty pharmacy to ship your treatment to you
  • Connect you with a Nurse Educator
  • Serve as a point of contact throughout your treatment journey and provide additional resources as needed

Your PAM will:

  • Work with you to address your insurance or access-related issues
Options for financial assistance
  • OnePath Co-Pay Assistance Program
    • For patients enrolled in OnePath and with commercial insurance (Other eligibility requirements apply)
    • 100% coverage for eligible out-of-pocket expenses up to the program maximum regardless of financial status
    • Eligible co-pay expenses may include deductibles and co-insurance
  • OnePath may be able to provide you with information about other financial assistance options
At-home injection training

Your Patient Support Manager (PSM) will connect you with a specially trained Nurse Educator who will provide injection training in your own home

Your Nurse Educator will:

  • Deliver the Q-Cliq Pen and demonstrate how to assemble it
  • Walk you through the reconstitution and administration process for the first 3 cartridges (Days 1, 15, and 29 of treatment)
  • Call you after each training to follow up and answer questions
  • Be available via phone when you are mixing the cartridge alone for the first time

You can call OnePath to be connected to a registered nurse anytime at 866-888-0660. OnePath’s normal business hours are 8:30 AM – 8:00 PM ET. Outside of normal business hours, a nurse will return your call within one hour.

How to enroll in OnePath

To enroll in OnePath, you and your doctor will first need to fill out a OnePath Start Form. Your doctor’s office will then submit the completed form to OnePath. Additional forms may be required.

Contact OnePath

For more information about OnePath call 1-866-888-0660. Patient Support Managers are available to speak with you Monday through Friday, 8:30 AM to 8:00 PM ET.

Onepath Nurse
Onepath Nurse
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Important Safety Information

What is the most important information I should know about NATPARA?

Warning: Possible bone cancer (osteosarcoma).

  • During animal drug testing, NATPARA caused some rats to develop a bone cancer called osteosarcoma.
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Important Safety Information

What is the most important information I should know about NATPARA?

Warning: Possible bone cancer (osteosarcoma).

  • During animal drug testing, NATPARA caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take NATPARA will have a higher chance of getting osteosarcoma. Tell your doctor right away if you have pain in any areas of your body that does not go away, or any new or unusual lumps or swelling under your skin that is tender to touch.
  • NATPARA is only available through the NATPARA Risk Evaluation and Mitigation Strategy (REMS) Program. The purpose of the NATPARA REMS program is to inform patients about the potential risk of osteosarcoma associated with the use of NATPARA. For more information about this REMS program, call 1-855-NATPARA (628-7272) or go to www.NATPARAREMS.com.

NATPARA may cause other serious side effects, including:

High blood calcium (hypercalcemia)

  • NATPARA can cause some people to have a higher blood calcium level than normal.
    • Your doctor should check your blood calcium before you start and during your treatment with NATPARA.
    • Tell your doctor if you have nausea, vomiting, constipation, low energy, or muscle weakness. These may be signs that you have too much calcium in your blood.

Low blood calcium (hypocalcemia)

  • People who stop using or miss a dose of NATPARA may have an increased risk of severe low blood calcium levels.
  • Tell your doctor if you have tingling of your lips, tongue, fingers and feet, twitching of face muscles, cramping of feet and hands, seizures, depression, or have problems thinking or remembering.

Tell your doctor right away if you have any of these signs and symptoms of high or low blood calcium levels.

Who should not use NATPARA?

  • Do not use NATPARA if you are allergic to parathyroid hormone or any of the ingredients in NATPARA.

What should I tell my healthcare provider before using NATPARA?

  • Before you start using NATPARA, tell your doctor about all of your medical conditions. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NATPARA?

  • NATPARA may cause serious side effects like allergic (hypersensitivity) reaction, including anaphylaxis. Tell your healthcare provider or get emergency medical help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, lips, mouth, or tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • fast heartbeat
    • itching
    • rash
    • hives
  • The most common side effects of NATPARA include: tingling, tickling, or burning feeling of the skin, low or high blood calcium, headache, nausea, reduced sense of touch or sensation, diarrhea, vomiting, pain in joints, too much calcium in urine, and pain in limbs.

These are not all the possible side effects of NATPARA. For more information, talk with your doctor.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Prescribing Information, Medication Guide, and Instructions for Use.