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Takeda will discontinue global manufacturing of NATPARA by the end of 2024. Learn How This May Affect You

Dosing Guidelines for NATPARA1

NATPARA is a self-administered, once-daily, subcutaneous injection into alternating thighs.1 The goal of NATPARA treatment is to achieve serum calcium within the lower half of the normal range.

Before initiating NATPARA and during treatment with NATPARA

  • Confirm 25-hydroxyvitamin D stores are sufficient. If insufficient, replace to sufficient levels per standard of care
  • Confirm serum calcium is above 7.5 mg/dL before starting NATPARA


  • 1

    Initiate NATPARA 50 mcg once daily as a subcutaneous injection in the thigh (alternate thigh every day)

  • 2

    In patients using active forms of vitamin D, decrease the dose of active vitamin D by 50%, if serum calcium is above 7.5 mg/dL

  • 3

    In patients using calcium supplements, maintain calcium supplement dose

  • 4

    Measure serum calcium concentration within 3 to 7 days



  • The dose of NATPARA may be increased in increments of 25 mcg every 4 weeks, up to a maximum daily dose of 100 mcg, if serum calcium cannot be maintained above 8 mg/dL without an active form of vitamin D and/or oral calcium supplementation
  • The dose of NATPARA may be decreased to as low as 25 mcg per day if total serum calcium is consistently above 9 mg/dL after the active form of vitamin D has been discontinued and calcium supplement has been decreased to a dose sufficient to meet daily requirements

REMEMBER: After a NATPARA dose change, monitor clinical response as well as serum calcium. Adjust active vitamin D and calcium supplements per steps 4-6 if indicated.

Graph of titrate dosage.

The recommended NATPARA dose is the minimum dose required to prevent both hypocalcemia and hypercalciuria.

No dose adjustment is recommended in patients with mild to moderate renal or hepatic impairment.



Once a maintenance dose is achieved, regularly monitor per standard of care:

  • Serum calcium
  • 24-hour urinary calcium

The maintenance dose should be the lowest dose that achieves a total serum calcium (albumin-corrected) within the lower half of the normal total serum calcium range (ie, approximately 8 and 9 mg/dL), without the need for active forms of vitamin D and with calcium supplementation sufficient to meet daily requirements.

After 24 weeks, the majority of NATPARA patients had been titrated up from the starting dose of 50 mcg.

Dose distribution at end of treatment

Graph of dose distribution at end of treatment.

*This dose was not part of the study.

Interruption or Discontinuation

Abrupt interruption or discontinuation of NATPARA can result in severe hypocalcemia. Resume treatment with, or increase the dose of, an active form of vitamin D and calcium supplements if indicated in patients interrupting or discontinuing NATPARA, and monitor for signs and symptoms of hypocalcemia and serum calcium levels. In the case of a missed dose, the next NATPARA dose should be administered as soon as reasonably feasible and additional exogenous calcium should be taken in the event of hypocalcemia. For full dosage and administration instructions, please see the full Prescribing Information section 2.

Reference: 1. NATPARA [package insert]. Shire Pharmaceuticals, Inc.

NATPARA® and the NATPARA Logo® are registered trademarks of Takeda Pharmaceuticals, U.S.A,. Inc.