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NATPARA® is a parathyroid hormone indicated as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. Because of the potential risk of osteosarcoma, NATPARA is recommended only for patients who cannot be well-controlled on calcium supplements and active forms of vitamin D alone. NATPARA was not studied in patients with hypoparathyroidism caused by calcium-sensing receptor mutations. NATPARA was not studied in patients with acute post-surgical hypoparathyroidism.

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NATPARA® is a parathyroid hormone indicated as an adjunct to calcium and vitamin D to control hypocalcemia in patients with hypoparathyroidism. Because of the potential risk of osteosarcoma, NATPARA is recommended only for patients who cannot be well-controlled on calcium supplements and active forms of vitamin D alone. NATPARA was not studied in patients with hypoparathyroidism caused by calcium-sensing receptor mutations. NATPARA was not studied in patients with acute post-surgical hypoparathyroidism.

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Managing
Hypoparathyroidism

Managing hypoparathyroidism requires careful monitoring2

In stable patients:

  • Serum calcium, phosphorous/phosphate, magnesium, BUN/creatinine and eGFR at least yearly
  • 24-hour urine collection for calcium and creatinine yearly

During dose adjustments:

  • More frequent monitoring, often several times per week, until a stable serum calcium concentration is achieved

For dosing and monitoring specific to NATPARA, click here.

Aim for low-normal, albumin-corrected total serum calcium levels2,3

For patients being treated for hypoparathyroidism, serum calcium levels are typically maintained at the lower end of the normal range (approximately 8.0 to 9.0 mg/dL).2

Albumin-corrected total serum
calcium levels1-4

References: 1. NATPARA [package insert]. Shire-NPS Pharmaceuticals, Inc. 2. Brandi ML, Bilezikian JP, Shock D, et al. Management of hypoparathyroidism: summary statement and guidelines [published online ahead of print March 4, 2016]. J Clin Endocrinol Metab. 2016;101(6):2273-2283. doi: 10.1210/jc.2015-3907. 3. Shoback D. Clinical Practice. Hypoparathyroidism. N Engl J Med. 2008;359(4):391-403. 4. Fong J, Khan A. Hypocalcemia: updates in diagnosis and management for primary care. Can Fam Physician. 2012;58(2):158-162.

NATPARA®, OnePath® and Q-Cliq™ are trademarks or registered trademarks of Shire, a Takeda company.

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