NATPARA’s active ingredient is a recombinant human parathyroid hormone (rhPTH)1
It contains 84 amino acids and has a terminal half-life of approximately 3 hours1
Amino acid sequence of PTH1
NATPARA is administered once per day1
Mean (±SE) unadjusted PTH and albumin-corrected serum calcium concentration following 100 mcg SC administration in patients with hypoparathyroidism 1
Treatment with NATPARA increases serum calcium levels, which are sustained for more than 24 hours after administration.
Mean peak serum calcium levels are reached between 10 and 12 hours following a single subcutaneous injection, and the increase in serum calcium above baseline is sustained for more than 24 hours after administration.
Peak plasma concentrations of NATPARA occur within 5 to 30 minutes with a second, usually smaller, peak at 1 to 2 hours.
Reference: 1. NATPARA [package insert]. Shire-NPS Pharmaceuticals, Inc.